Perio Aid® Formula: Chlorhexidine + Cetylpyridinium Chloride

The prevention and treatment of periodontal and peri-implant diseases should be aimed at disorganizing oral biofilm and reducing the bacteria that cause these diseases.

To achieve active control of the pathogenic bacteria that cause periodontal and peri-implant disease, treatment followed by periodontal maintenance in the dental office is essential together with home support using antiseptics.

Numerous scientific studies have been conducted over the years in search of the most complete antiseptic to ensure maximum oral asepsis with optimal safety during the different phases of periodontal and peri-implant treatment and maintenance. Currently, Chlorhexidine is considered to be the gold standard (antiseptic of choice) for periodontal and peri-implant treatment and maintenance, although not all chlorhexidine formulations ensure the same effectiveness. It is very important to study the different components in a formula and also to study the formulation itself in order to avoid possible interactions1.



Perio Aid®’s specific formula, with Chlorhexidine (CHX) and Cetylpyridinium chloride (CPC), is the first antiseptic combination to boast scientifically-backed superior efficacy:

Better results have been obtained when CPC is added to CHX formulations2.

Both molecules are cationic, and so there is no negative interaction between them; they act synergistically. By adding CPC to the formula, CHX’s spectrum of action increases, as does its antibacterial activity3.









  1. Jenkins S, Addy M, y Newcombe RG. Comparision of two commercially available chlorhexidine mouthrinses: II Effects on plaque reformation, gingivitis, and tooth staining. Clin Prev Dent. 1989 Nov-Dec; 11 (6): 12-6.
  2. Bascones A, Morantes S. Antisépticos orales. Revisión de la literatura y prospectiva actual. Av Periodon Implantol 2006:18,1:80-7.
  3. Herrera D., Roldán S., Santacruz I., Santos S., Masdevall M., Sanz M. Differences in antimicrobial activity of four comercial 0,12% chlorhexidine mouthrinse formulations: an in vitro contact test and salivary bacterial counts study. J Clin Periodontol 2003; 30: 307-314.